Study Suggests Significant NSAID Side Effects on Female Fertility
A new study has determined that the common non-steroidal anti-inflammatory drugs (NSAIDs) “Diclofenac”, “Naproxen” and “Etoricoxib” can decrease female fertility significantly. The effect was measured already after 10 days of intake[1. “https://www.eurekalert.org/pub_releases/2015-06/elar-nad061015.php”].
Worldwide, more than 30 million people take these drugs every day.
These non-steroidal anti-inflammatory drugs (NSAIDs) have previously shown to have a negative effect on fertility of animals[2. “https://www.ncbi.nlm.nih.gov/pubmed/16493584”]. In 2015, results of a human study with 39 women was presented by Dr. Sami Salman. 39 women with back pain received either
Diclofenac (100 mg per day), or
Naproxen (500 mg, twice a day), or
Etoricoxib (90 mg, once a day).
After 10 days of intake, progesteron levels of the women taking these pharmaceuticals were significantly lower. Only 6% of these women had their ovulation, while nearly all women taking a placebo (ineffective control substance) had regular ovulation and a normal progesteron level.
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Conclusion
By itself, the study is too small to attract international attention. Its findings, however, are alarming.
Women, who experience arthritis from an early age and who are keen on mothering a child conceive must be be even more careful with taking NSAIDs. They may have a significant impact on their reproductive system.
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Bibliography
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Dr. Kooner is Deputy Director of The Advanced Fertility Center of Chicago and has been a Specialist in Fertility Treatment since 1999.
As well as the areas that the clinic specialises in general, he is particularly interested in managing oocyte donation, female same-sex couples, single women having sperm donation and those considering egg freezing.
Dr. Kooner regularly speaks at fertility meetings. He has published in national journals and constantly contributes to the fertility research and publications from Advanced Fertility Center of Chicago.
